ripk2 inhibitor 1 — TargetMol Chemicals

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Compounds

Cat No.	Product Name	Synonyms	Targets
T5401	GSK2983559 active metabolite	GSK2983559,RIPK2 inhibitor 1,RIPK2-IN-1	RIP kinase
	GSK2983559 active metabolite (RIPK2-IN-1) is a potent, selective receptor-interacting protein-2 (RIP2) kinase inhibitor.		RIP kinase
T63544	RIPK3-IN-1
	RIPK3-IN-1 is a type II RIPK3DFG-out site inhibitor (IC50: 9.1 nM) that inhibits RIPK1 (IC50: 5.5 μM) and RIPK2 (IC50>10 μM). RIPK3-IN-1 is a c-Met kinase inhibitor (IC50: 1.1 μM).
T79600	Zharp2-1		RIP kinase
	Zharp2-1, a RIPK2 inhibitor, inhibits the transcription of inflammatory cytokines induced by MDP-induced or Listeria monocytogenes infection and alleviates MDP-induced peritonitis symptoms in mice, which can be used for ...		RIP kinase
T62783	RIPK2-IN-1
	RIPK2-IN-1 (compound 18f) is a potent inhibitor of RIPK2 (IC50: 51 nM) and also inhibits ALK2 (IC50: 5 nM).
T74572	RIPK2-IN-2
	RIPK2-IN-2 (example 25) is a RIP2 kinase PROTAC inhibitor that effectively blocks RIP2-dependent proinflammatory signaling and regulates RIP2 kinase activity in autoinflammatory diseases [1].
T79352	RIPK2/3-IN-1		RIP kinase
	RIPK2/3-IN-1 is a potent inhibitor of both RIPK2 and RIPK3 kinases, exhibiting IC50 values of 3 nM for RIPK2 and 117 nM for RIPK3. Additionally, in a 14-TriLAN-Gly/NOD1 THP-1 cell-based NF-κB reporter assay, RIPK2/3-IN-1...		RIP kinase
T78597	RIPK2-IN-3		RIP kinase
	RIPK2-IN-3 (FCG806791773) is a receptor-interacting protein kinase 2 (RIPK2) inhibitor with an IC50 value of 6.39 μM against recombinant truncated RIPK2. It is applicable in the study of inflammation and cancer [1].		RIP kinase
T73867	HTH-01-091 TFA
	HTH-01-091 TFA, a potent and selective inhibitor of maternal embryonic leucine zipper kinase (MELK), exhibits an IC50 of 10.5 nM. Besides its primary target, it also inhibits PIM1/2/3, RIPK2, DYRK3, smMLCK, and CLK2, pos...